Thursday, October 11
Mathematics Colloquium
03:35 PM - 04:30 PM
Location: Science Center Room 323
Cost: Free

Speaker: Yang Liu , Wright State University

Host: Ying-Ju Tessa Chen

Title: Multivariate Association Analysis with Somatic Mutation Data

Abstract: Somatic mutations are the driving forces for tumor development, but it is challenging to analyze somatic mutations, because the majority of somatic mutations occur at low frequencies. Furthermore, cancer is a complex disease and is often accompanied by multiple traits; how to jointly analyze these traits to identify important somatic mutations poses additional challenges. In this talk, I will introduce a statistical approach, named as SOMAT, for detecting somatic mutations associated with multiple cancer-related traits. The approach provides a flexible framework for analyzing continuous, binary, or a mixture of both types of traits, and is statistically powerful and computationally efficient. In addition, we propose a data-adaptive procedure for effectively combining test statistics to enhance statistical power. The advantage of SOMAT is demonstrated through both simulations and an exome-sequencing study.

Refreshments are available at 3:00 PM in SC 313F.

The department colloquia are held every Thursday (excluding holidays) at 3:35 pm in room SC 323 unless otherwise noted. All are invited to attend. 

Contact Information:
Name: Paul Eloe