Kristen Comfort

Associate Professor; Associate Chair; Director, Bioengineering Graduate Program

Full-Time Faculty


Email: Kristen Comfort
Phone: 937-229-2627

Kettering Laboratories Room 522A-1


Selected Publications

  • Luby, A.O., E.K. Breitner, and K.K. Comfort. 2015. Preliminary protein corona formation stabilizes gold nanoparticles and improves deposition efficiency. Appl. Nanosci. doi: 10.1007/s13204-015-0501-z
  • Breitner, E.K., S.M. Husain, and K.K. Comfort. 2015. The role of biological fluid and dynamic flow in the behavior and cellular interactions of gold nanoparticles. J. Nanobiotechnol. 13:56 (September 5). doi:10.1186/s12951-015-0117-1
  • Hussain, S.M., D.B. Warheit, S.P. Ng, K.K. Comfort, C.M. Grabinski, and L.K. Braydich-Stolle. 2015. At the crossroads of nanotoxicology in vitro: Past achievements and current challenges. Invited Review. Toxicological Sciences 147: 5-16.
  • Braydich-Stolle, L.K., E.K. Breitner, K.K. Comfort, J.J. Schlager, and S.M. Hussain. 2014. Dynamic characterization of silver nanoparticles in physiological fluids: Toxicological implications. Langmuir 30:15309-15316.
  • Comfort, K.K., E.I. Maurer, and S.M. Hussain 2014. Slow release of ions from internalized silver nanoparticles modifies the epidermal growth factor signaling response. Colloids and Surfaces B:Biointerfaces 123: 136-142.
  • Comfort, K.K., L.K. Braydich-Stolle, E.I. Maurer, and S.M. Hussain. 2014. Less is more: In vitro chronic, low-level nanomaterial exposure provides a more meaningful toxicity assessment. ACS Nano 8: 3260-3271.
  • Untener, E.A., K.K. Comfort, E.I. Mauer, C.M. Grabinski, D.A. Comfort, and S.M. Hussain. 2013. Tannic acid coated gold nanorods demonstrate a distinctive form of endosomal uptake and unique distribution within cells. ACS Applied Materials and Interfaces 5: 8366-8373.
  • DeBrosse, M.C., K.K. Comfort, E.A. Untener, D.A. Comfort, and S.M. Hussain. 2013. High aspect ratio gold nanorods displayed augmented cellular internalization and surface chemistry mediated cytotoxicity. Materials Science and Engineering: C 33: 4094-4100.
  • Stacy, B.M., K.K. Comfort, D.A. Comfort, and S.M. Hussain. 2013. In vitro identification of gold nanorods through hyperspectral imaging. Plasmonics 8: 1235-1240.
  • Comfort, K.K., E.I. Maurer, L.K. Braydich-Stolle, and S.M. Hussain. 2011. Interference of silver, gold, and iron oxide nanoparticles on epidermal growth factor signal transduction in epithelial cells. ACS Nano 5:10000-10008.
Research and Work
  • National Research Council Postdoctoral Fellow at Air Force Research Laboratories
  • Catalent Pharma Solutions

Courses Taught

  • Material and Energy Balances (CME 203)
  • Chemical Engineering Thermodynamics (CME 311)
  • Adv. Math for Chemical Engineers (CME 381)
  • Fluid Flow and Heat Transfer (CME 465)
  • Transport Phenomena in Biological Systems (CME 523)
  • Research Methods (CME 597)


  • Ph.D., Chemical Engineering, North Carolina State University, 2007
  • M.S., Chemical Engineering, North Carolina State University, 2006
  • B.Cm.E., Chemical Engineering, University of Dayton, 2002

Professional Activities

  • Certified Academic Coach
  • American Institute of Chemical Engineers, Member
  • Material Research Society, Member
  • Society of Biological Engineering, Member
  • Sigma Xi, Member and Secretary of UD Chapter
  • Tau Beta Pi, Member

Research Interests

  • Development of enhanced cellular models to bridge the in vitro – in vivo gap
  • Evaluation of nanomaterial-induced biological effects, with a focus on the inflammatory and signal transduction responses
  • Characterization of nanomaterial behavior under physiologically relevant exposure conditions