Directory

Profile

Dr. Rajput earned his Bachelor of Veterinary Science and Animal husbandry degree as well as Master of Veterinary Sciences (Veterinary Epidemiology and Preventive Medicine) from G.B. Pant University of Agriculture and Technology, Pantnagar, India, in 2003 and 2005, respectively. After receiving his Masters degree, He worked at the Department of Animal Husbandry, Government of Uttarakhand, India as a Veterinary Officer. In 2006, He joined the College of Veterinary Science at G.B. Pant University of Agriculture and Technology, Pantnagar, India, as Assistant Professor.

In 2009, He moved to South Dakota State University for his Ph.D. He completed his Ph.D. in Veterinary Virology and Immunology in 2013. Dr. Rajput worked with Medgene Labs in Brookings, S.D., as Research Scientist and received further postdoctoral training at South Dakota State University and Michigan State University before joining Arkansas Tech University as Assistant Professor in 2018. In 2021, Dr. Rajput joined the Department of Biology at University of Dayton in Microbiology.

Courses taught

• BIO 411: General Microbiology
• BIO 411L: General Microbiology Laboratory

Professional activities and affiliations

• American Society for Microbiology
• American Society for Virology
• Indian Society for Veterinary Medicine

Research interests

RNA viruses are more prone for mutation and generally exhibit a smaller genome size than DNA viruses. Dr. Rajput’s lab is focusing on host-RNA virus interaction. Host- virus interaction influences each other. During infection, viruses modulate the host responses and at the same time host defense mechanisms influence the virus. Understanding the host-pathogen interaction provides critical information regarding RNA virus replication, disease pathophysiology and helps us in developing new targeted therapeutic interventions for viral infection.

Publications and presentations

Karim, A., Rajput, M.K.S., Elmowalid, G., Sobraske, J., Thakur, N., Abdallah, H., Abdelsamiee, A., Chase, C.2020. The Effect of Bovine Viral Diarrhea Virus (BVDV) strains and the corresponding Infected-Macrophages’Supernatant on Macrophage Inflammatory. Viruses. 2020 June 29; 12(7):701. doi: 10.3390/v12070701.

Thakur, N., Evans, H., Abdelsalam, K., Farr, A., Rajput, MKS, Chase, CCL. Bovine Viral Diarrhea VirusCompromises Neutrophil’s Functions in Strain Dependent Manner. Microbial pathogenesis. 149:104515. doi:10.1016/j.micpath.2020.104515. Epub 2020 Sept. 22. PMID: 32976968.

Rajput, MKS, Darweesh MF., Braun LJ, Mansour SM., Chase CCL. 2020. Comparative humoral immune response against cytopathic or non-cytopathic bovine viral diarrhea virus infection. Research in Veterinary Science. 129: 109-116. Doi: 10.1016/j.rvsc.2020.01.012 

D’Costa, S., Ayyadurai, S., Gibson, AJ.,  Mackey, E., Rajput, MKS., Sommerville, LJ, Wilson, N., Li, Y., Kubat, E.,Kumar, A., Hariharan, S.,  Bhargava, A., Moeser, A. 2018. Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of anaphylaxis and Stress-Induced Intestinal Permeability. Journal of Allergy and Clinical Immunology. 143(5):1865-1877. doi: 10.1016/j.jaci.2018.08.053.  

Rajput, MKS., Kesharwani, S., Kumar, S., Muley, P., Narisrtty, S., Tummala, H. 2018. Dendritic Cell Targeted Nanovaccine Delivery System Prepared with an Immune-Active Polymer. ACS Applied Materials & Interfaces. doi: 10.1021/acsami.8b02019.  

Darweesh MF., Rajput MKS., Braun LJ., Rohila JS., Chase CCL. 2018. BVDV Npro protein mediates the BVDV induced immunosuppression through interaction with cellular S100A9 protein. Microbial Pathogenesis. doi: 10.1016/j.micpath.2018.05.047  

Kesharwani, S., Bakkari, M., Rajput, MKS., Dachineni, R., Chaitanya, V., Tummala, H. 2018.  Site-Directed Non-covalent Polymer-Drug Complexes for Inflammatory Bowel Disease (IBD): Formulation Development, Characterization, and Pharmacological Evaluation. Journal of Controlled Release. 28;290:165-179. doi: 10.1016/j.jconrel.2018.08.004.  

Rajput, MKS., Abdelsalam, K., Darweesh, MF., Lyle, B., Kerkvliet, J., Hoppe, A., Chase, CCL. 2017 Both cytopathic and non-cytopathic Bovine viral diarrhea virus (BVDV) induced autophagy at similar rate in in vitro culture. Veterinary immunology and immunopathology. (193), 1-9. 10.1016/j.vetimm.2017.09.006.

Moeser, AJ., Pohl, C., Rajput, MKS. 2017. Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs. Animal Nutrition. 1-9. http://dx.doi.org/10.1016/j.aninu.2017.06.003  

Kumar, S., Kesharwani, S.,  Kuppast, B., Rajput, MKS., Bakkari, M., Tummala, H. 2016. Discovery of Inulin Acetate as a Novel Immune-Active Polymer and Vaccine Adjuvant: Synthesis, Material Characterization, and Biological Evaluation as a Toll-Like Receptor-4 Agonist. Journal of Materials Chemistry B. 10.1039/C6TB02181F.  

Chase CCL, Thakur N, Darweesh MF., Morarie-Kane, S, Rajput MK. 2015. Immune response to bovine viral diarrhea virus-looking at newly defined targets. Animal Health Research Reviews. 16(1), 4–14. doi:10.1017/S1466252315000110  

Darweesh MF, Rajput MKS, Braun LJ, Ridpath JF, Neill JD and Chase CCL. 2015. Characterization of the cytopathic BVDV strains isolated from 13 mucosal disease cases arising in a cattle herd. Virus Research, 195, 141–147. doi:10.1016/j.virusres.2014.09.015.  

Rajput MKS, Darweesh MF, Park K, Braun L.J., Mwangi W, Young AJ, Chase, CC. 2014. The effect of bovine viral diarrhea virus (BVDV) strains on bovine monocyte-derived dendritic cells (Mo-DC) phenotype and capacity to produce BVDV. Virology Journal, 11(1), 44. doi:10.1186/1743-422X-11-44.  

Elbakrey RM, El Sisi MA, Mansour SM, Ahmed HH, Rajput MKS, Eid AA. 2014. Cleavage site stability of Egyptian highly pathogenic avian influenza viruses in backyard chickens during 2009-11. Journal of Microbiology, Immunology, and Infection 48(1), 28–35. doi:10.1016/j.jmii.2013.12.002